usability - Is it wrong to have your primary actions in red?

We're using red as the colour for primary Actions. This can be in the form of a button.

In terms of usability, what are the downsides. Are there any upsides at all?

An example for using red coloured buttons is gmail I suppose.

UPDATE: Thanks for the answers about cultural factors. It's good to be reminded of it, but as @rk says, that importance is starting to diminish and I'd like to steer the discussion in another direction.

Answer

It makes no sense to consider a single color. You have to consider the color in its context. No one was ever stopped from drinking Coca-Cola because of the red in the logo.

So long as the context and the surroundings are unknown, it is impossible to give an informed opinion on a choice of color.